methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

Base Information

Chemical Name:methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate
CAS No.:1255860-38-8
Molecular Formula:C₂₂H₂₈N₃O₁₀P
Molecular Weight:525.452
Hs Code.:

methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

Synonyms:methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

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Chemical Property of methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

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Technology Process of methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

There total 9 articles about methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1255860-33-3
1-[(4R,5R,7R,8R)-8-hydroxy-7-(hydroxyl-methyl)-1,6-dioxaspiro[3.4]octan-5-yl]pyrimidine-2,4(1H,3H)-dione

: 261909-35-7
phenyl (methyl 2-amino-2-methylpropanoate) phosphorochloridate

: 1255860-38-8
methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm4015422

Reference yield:

: 1255860-30-0
1-((2R,3R,4R,5R)-3-allyl-4-(benzyloxy)-5-(benzyloxymethyl)-3-hydroxytetra-hydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 1255860-38-8
methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

3: pyridine / 2 h

4: sodium hydride / tetrahydrofuran / 2 h / 20 °C

5: palladium(II) hydroxide; hydrogen / tetrahydrofuran / 18 h / 25 °C / 775.74 Torr / Inert atmosphere

6: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydrogen; palladium(II) hydroxide; sodium hydride; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jm4015422

Reference yield:

: 1255860-32-2
1-[(4R,5R,7R,8R)-8-(benzyloxy)-7-(benzyloxy-methyl)-1,6-dioxaspiro[3.4]octan-5-yl]pyrimidine-2,4(1H,3H)-dione

: 1255860-38-8
methyl 2-((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphorylamino)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium(II) hydroxide; hydrogen / tetrahydrofuran / 18 h / 25 °C / 775.74 Torr / Inert atmosphere

2: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With 1-methyl-1H-imidazole; hydrogen; palladium(II) hydroxide; In tetrahydrofuran;
DOI:10.1021/jm4015422