4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester
• CAS No.: 910127-07-0
• Molecular Formula: C₂₃H₂₉N₃O₄
• Molecular Weight: 411.501

Synonyms:4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester

Chemical Property of 4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester

There total 2 articles about 4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenylmethyl 1-piperazinecarboxylate (31166-44-6) + benzyl N-(3-bromopropyl)carbamate (39945-54-5) → 4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester (910127-07-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester (910127-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / aq. NaOH / 0 - 20 °C

2: 70 percent / K₂CO₃ / dimethylformamide / 5 h / 90 °C

With sodium hydroxide; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm060732n

Reference yield: 100.0%

4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester (910127-07-0) → 3-(piperazin-1-yl)propan-1-amine (34885-02-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 16h;

upstream raw materials:

phenylmethyl 1-piperazinecarboxylate

benzyl N-(3-bromopropyl)carbamate

benzyl chloroformate

Downstream raw materials:

3-(piperazin-1-yl)propan-1-amine

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