(S)-2-{(S)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-{(S)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester
• CAS No.: 145763-46-8
• Molecular Formula: C₄₄H₅₁N₅O₁₁S
• Molecular Weight: 857.982
• Mol file: 145763-46-8.mol

Synonyms:(S)-2-{(S)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Chemical Property of (S)-2-{(S)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(S)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

There total 28 articles about (S)-2-{(S)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-benzyloxycarbonyl-O-tosyl-(S)tyrosyl-glycyl-glycyl-(Z)dehydrophenylalanyl-(S)leucine methyl ester (106111-08-4) → (S)-2-{2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester (145763-46-8,145763-47-9,145763-49-1)

Guidance literature:

With [Rh((R,R)-DIPAMP)(COD)]BF₄; hydrogen; In methanol; for 48h; under 7500.6 Torr;

DOI:10.1016/S0957-4166(00)82083-2

Reference yield: 90.0%

N-benzyloxycarbonyl-O-tosyl-(Z)dehydrotyrosyl-glycyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester (145763-39-9) → (S)-2-{(S)-2-[2-(2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester (145763-46-8,145763-47-9,145763-49-1)

Guidance literature:

With [Rh((R,R)-DIPAMP)(COD)]BF₄; hydrogen; In methanol; for 48h; under 13501.1 Torr;

DOI:10.1016/S0957-4166(00)82083-2

Reference yield:

N-benzyloxycarbonyl-O-tosyl-(S)tyrosyl-glycyl-glycyl-(Z)dehydrophenylalanyl-(S)leucine methyl ester (106111-08-4) → (S)-2-{(R)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester (145763-47-9) + (S)-2-{(S)-2-[2-(2-{(S)-2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester (145763-46-8)

Guidance literature:

With hydrogen; RhCl^(1-)bppm; In methanol; at 15 ℃; under 750.06 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(00)84699-7

upstream raw materials:

N-benzyloxycarbonyl-O-tosyl-(S)tyrosyl-glycyl-glycyl-(Z)dehydrophenylalanyl-(S)leucine methyl ester

Z-Gly-PhSer-OH

N-benzyloxycarbonyl-O-tosyl-(S)tyrosine

(S)-(O)-Ts-Tyr-OH