tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane

Base Information

Chemical Name:tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane
CAS No.:1446840-04-5
Molecular Formula:C₂₁H₂₈ClFOSi
Molecular Weight:378.99
Hs Code.:

Synonyms:tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane

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Chemical Property of tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane

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Technology Process of tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane

There total 3 articles about tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1446839-66-2
1-(2-((tert-butyldimethylsilyl)oxy)phenyl)-3-(4-fluorophenyl)propan-1-ol

: 1446840-04-5
tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane

Guidance literature:: With thionyl chloride; In toluene; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ja405833m

Reference yield:

: 116585-12-7
2-((tert-butyldimethylsilyl)oxy)benzaldehyde

: 1446840-04-5
tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; tetrahydrofuran / 3 h / Inert atmosphere; Cooling with ice

2: thionyl chloride / toluene / 18 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/ja405833m

Reference yield:

: 157977-55-4
(4-fluorophenylethyl)magnesium bromide

: 1446840-04-5
tert-butyl-(2-(1-chloro-3-(4-fluorophenyl)propyl)phenoxy)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; tetrahydrofuran / 3 h / Inert atmosphere; Cooling with ice

2: thionyl chloride / toluene / 18 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/ja405833m