C₂₃H₂₂ClN₃O₃

Base Information

• Chemical Name: C₂₃H₂₂ClN₃O₃
• CAS No.: 367946-15-4
• Molecular Formula: C₂₃H₂₂ClN₃O₃
• Molecular Weight: 423.899
• Mol file: 367946-15-4.mol

Synonyms:C₂₃H₂₂ClN₃O₃

Chemical Property of C₂₃H₂₂ClN₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₂ClN₃O₃

There total 1 articles about C₂₃H₂₂ClN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloromethyl-2-(2-chlorophenyl)-5-propyloxazole (1311277-26-5) + 6-acetamido-3-methyl-1,2-benzisoxazole (145508-92-5) → C23H22ClN3O3 (367946-15-4)

Guidance literature:

6-acetamido-3-methyl-1,2-benzisoxazole; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.916667h; Inert atmosphere;

4-chloromethyl-2-(2-chlorophenyl)-5-propyloxazole; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.03.053

Reference yield:

C23H22ClN3O3 (367946-15-4) → C21H20ClN3O2 (367946-16-5)

Guidance literature:

C₂₃H₂₂ClN₃O₃; With hydrogenchloride; water; acetic acid; for 24h; Reflux;

With sodium hydroxide; In water; Cooling with ice;

DOI:10.1016/j.bmc.2011.03.053

Reference yield:

C23H22ClN3O3 (367946-15-4) → 2-[3-[2-[2-(2-chlorophenyl)-5-propyl-4-oxazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid (367945-78-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; water; acetic acid / 24 h / Reflux

1.2: Cooling with ice

2.1: sulfuric acid; water; sodium nitrite / 3.33 h / 0 - 130 °C

3.1: potassium carbonate / butanone / 45 h / Reflux

4.1: lithium hydroxide monohydrate / ethanol; water / 2 h / Reflux

4.2: Cooling with ice

With hydrogenchloride; lithium hydroxide monohydrate; sulfuric acid; water; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water; butanone;

DOI:10.1016/j.bmc.2011.03.053

upstream raw materials:

4-chloromethyl-2-(2-chlorophenyl)-5-propyloxazole

6-acetamido-3-methyl-1,2-benzisoxazole

Downstream raw materials:

2-[3-[2-[2-(2-chlorophenyl)-5-propyl-4-oxazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

C₂₁H₂₀ClN₃O₂

C₂₁H₁₉ClN₂O₃

C₂₇H₂₉ClN₂O₅