tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

Base Information

Chemical Name:tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate
CAS No.:874360-10-8
Molecular Formula:C₂₃H₂₇F₆N₅O₂
Molecular Weight:519.49
Hs Code.:

Synonyms:tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

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Chemical Property of tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

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Technology Process of tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

There total 12 articles about tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874359-92-9
tert-butyl [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

: 762240-92-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

: 874360-10-8
tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

: tert-butyl [(1S,2R,5R)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

Guidance literature:: tert-butyl [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate; 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride; With titanium tetrachloride; In dichloromethane; at 20 ℃;

With methanol; sodium cyanoborohydride; In dichloromethane; for 0.25h;

With sodium hydroxide; water; pH=13;

Reference yield:

: 874359-93-0
8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

: 874360-10-8
tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: POCl₃

2: hydrogen / Pd/C

3: acid

4: iodosobenzene; trimethylsilyl azide

5: lithium aluminum hydride

6: F^(1-)

7: decaborane / methanol

With lithium aluminium tetrahydride; Decaborane; trimethylsilylazide; iodosylbenzene; fluoride; hydrogen; trichlorophosphate; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2007.03.095

Reference yield:

: 874359-94-1
8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene

: 874360-10-8
tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / Pd/C

2: acid

3: iodosobenzene; trimethylsilyl azide

4: lithium aluminum hydride

5: F^(1-)

6: decaborane / methanol

With lithium aluminium tetrahydride; Decaborane; trimethylsilylazide; iodosylbenzene; fluoride; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2007.03.095