(Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:(Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide
CAS No.:1268630-78-9
Molecular Formula:C₁₅H₂₃NO₄S
Molecular Weight:313.418
Hs Code.:

Synonyms:(Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

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Technology Process of (Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

There total 4 articles about (Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1268631-13-5
C₂₁H₃₇NO₄SSi

: 1268630-78-9
(Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1002/chem.201002606

Reference yield: 60.0%

: cis-1-bromo-but-2-en-4-ol

: 29668-57-3
N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide

: 1268630-78-9
(Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

Guidance literature:: N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

cis-1-bromo-but-2-en-4-ol; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.joc.6b02260

Reference yield:

: 29668-57-3
N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide

: 1268630-78-9
(Z)-N-(2-hydroxy-2-methylpropyl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 16 h / Inert atmosphere; Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1002/chem.201002606