4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

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Chemical Name:4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one
CAS No.:426842-21-9
Molecular Formula:C₂₈H₃₅N₃O₄
Molecular Weight:477.604
Hs Code.:

Synonyms:4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

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Chemical Property of 4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

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Technology Process of 4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

There total 6 articles about 4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 109-01-3
1-methyl-piperazine

: 426842-19-5
2-[1-(4-bromo-phenyl)-meth-(E)-ylidene]-4,6-dimethoxy-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

: 426842-21-9
4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; for 12h; Heating;
DOI:10.1021/jm0108348

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 426842-21-9
4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / HCl / acetic acid / 24 h / 20 °C

2.1: 87 percent / H₂ / Pd/C / acetic acid; H₂O / 20 h / 20 °C / normal pressure

3.1: 3.5 h / 50 °C

3.2: 50 percent / AlCl₃ / 1 h / 100 °C

4.1: 41 percent / KOH / ethanol / 1 h / 20 °C

5.1: 55 percent / Pd₂(dba)3; racemic-BINAP; cesium carbonate / dioxane / 12 h / Heating

With hydrogenchloride; potassium hydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; acetic acid;
DOI:10.1021/jm0108348

Reference yield:

: 500-99-2
3,5-dimethoxyphenol

: 426842-21-9
4,6-dimethoxy-2-[1-[4-(4-methyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-7-(1-methyl-piperidin-4-yl)-benzofuran-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / HCl / acetic acid / 24 h / 20 °C

2.1: 87 percent / H₂ / Pd/C / acetic acid; H₂O / 20 h / 20 °C / normal pressure

3.1: 3.5 h / 50 °C

3.2: 50 percent / AlCl₃ / 1 h / 100 °C

4.1: 41 percent / KOH / ethanol / 1 h / 20 °C

5.1: 55 percent / Pd₂(dba)3; racemic-BINAP; cesium carbonate / dioxane / 12 h / Heating

With hydrogenchloride; potassium hydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; acetic acid;
DOI:10.1021/jm0108348