tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Base Information

Chemical Name:tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate
CAS No.:1240288-37-2
Molecular Formula:C₂₈H₃₁NO₅S₂
Molecular Weight:525.69
Hs Code.:

Synonyms:tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

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Chemical Property of tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

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Technology Process of tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

There total 9 articles about tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 859833-13-9
2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole

: 1240288-36-1
tert-butyl {4-bromo-2-[(3-propylsulfonylphenyl)ethynyl]phenoxy}acetate

: 1240288-37-2
tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Guidance literature:: With cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 120 ℃; for 0.166667h; Inert atmosphere; tube sealed; microwave irradiation;

Reference yield:

: 1240288-35-0
tert-butyl (4-bromo-2-iodophenoxy)acetate

: 1240288-37-2
tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; trans-bis(triphenylphosphine)palladium dichloride / 18 h / 70 °C

2: trans-bis(triphenylphosphine)palladium dichloride; cesium fluoride / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

With piperidine; trans-bis(triphenylphosphine)palladium dichloride; cesium fluoride; In 1,4-dioxane; water; 1: Sonogashira coupling / 2: Suzuki coupling;
DOI:10.1021/jm200866y

Reference yield:

: 153435-83-7
1-bromo-3-(propylsulfonyl)benzene

: 1240288-37-2
tert-butyl (4-(2,4-dimethyl-1,3-thiazol-5-yl)-2{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

1.2: 24 h / 60 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

3.1: piperidine; trans-bis(triphenylphosphine)palladium dichloride / 18 h / 70 °C

4.1: trans-bis(triphenylphosphine)palladium dichloride; cesium fluoride / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

With piperidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trans-bis(triphenylphosphine)palladium dichloride; tetrabutyl ammonium fluoride; triethylamine; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; water; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling / 3.1: Sonogashira coupling / 4.1: Suzuki coupling;
DOI:10.1021/jm200866y