3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

Base Information

Chemical Name:3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid
CAS No.:158980-62-2
Molecular Formula:C₄₀H₃₆O₈
Molecular Weight:644.721
Hs Code.:

Synonyms:3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

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Chemical Property of 3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

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Technology Process of 3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

There total 17 articles about 3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 158980-61-1
1,1-dimethylethyl 3,5-bis(benzyloxy)-4-<6-(benzyloxy)-2-formylbenzoyl>benzoate

: 158980-62-2
3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

Guidance literature:: With tetra-n-butylammonium permanganate; In pyridine; for 44h; Ambient temperature;
DOI:10.1021/jo952280k

Reference yield:

: 16534-12-6
3,5-dihydroxy-4-bromobenzoic acid

: 158980-62-2
3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / K₂CO₃ / dimethylformamide / 20 h / Ambient temperature

2: 95 percent / NaOH / H₂O / 12 h / 100 °C

3: 99 percent / CDI, DBU / dimethylformamide / 60 h / 40 °C

4: 48 percent / BuLi / tetrahydrofuran; hexane / 1.) -70 deg C, 10 min, 2.) -78 deg C, 20 min; warm to room temperature, 45 min

5: DMF, (COCl)2 / CH₂Cl₂ / 3 h / Ambient temperature

6: 81 percent / t-BuOK / tetrahydrofuran / 0.75 h / 0 °C

7: 51 percent / BuLi / tetrahydrofuran; hexane / 1 h / -72 °C

8: 97 percent / PDC / dimethylformamide / 8 h / Ambient temperature

9: 100 percent / Bu₄NMnO₄ / pyridine / 44 h / Ambient temperature

With sodium hydroxide; dipyridinium dichromate; n-butyllithium; oxalyl dichloride; tetra-n-butylammonium permanganate; potassium tert-butylate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; pyridine; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo952280k

Reference yield:

: 158980-57-5
3,5-dibenzyloxy-4-bromobenzoic acid tert-butyl ester

: 158980-62-2
3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 48 percent / BuLi / tetrahydrofuran; hexane / 1.) -70 deg C, 10 min, 2.) -78 deg C, 20 min; warm to room temperature, 45 min

2: DMF, (COCl)2 / CH₂Cl₂ / 3 h / Ambient temperature

3: 81 percent / t-BuOK / tetrahydrofuran / 0.75 h / 0 °C

4: 51 percent / BuLi / tetrahydrofuran; hexane / 1 h / -72 °C

5: 97 percent / PDC / dimethylformamide / 8 h / Ambient temperature

6: 100 percent / Bu₄NMnO₄ / pyridine / 44 h / Ambient temperature

With dipyridinium dichromate; n-butyllithium; oxalyl dichloride; tetra-n-butylammonium permanganate; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; pyridine; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo952280k