1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil

Base Information

• Chemical Name: 1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil
• CAS No.: 184226-14-0
• Molecular Formula: C₂₇H₂₆N₂O₁₂S
• Molecular Weight: 602.576
• Mol file: 184226-14-0.mol

Synonyms:1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil

Chemical Property of 1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil

There total 1 articles about 1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) + C25H26O12S → 1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil (184226-14-0)

Guidance literature:

With chloro-trimethyl-silane; trifluorormethanesulfonic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1080/07328319608002464

Reference yield: 90.0%

1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil (184226-14-0) → 1-(5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil (184226-17-3)

Guidance literature:

With hydrazine hydrate; In pyridine; acetic acid; at 25 ℃; for 16h;

DOI:10.1080/07328319608002464

Reference yield:

1-(2-O-acetyl-5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil (184226-14-0) → 2,2'-anhydro-1-(5,6-di-O-benzoyl-β-D-altrofuranosyl)uracil

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydrazine hydrate / pyridine; acetic acid / 16 h / 25 °C

2: 78 percent / DBU / toluene / 25 deg C, 1 h; 90 deg C, 15 min

With hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; acetic acid; toluene;

DOI:10.1080/07328319608002464

upstream raw materials:

uracil

Downstream raw materials:

1-(5,6-di-O-benzoyl-3-O-mesyl-β-D-glucofuranosyl)uracil