(S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester

Base Information

• Chemical Name: (S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester
• CAS No.: 914382-69-7
• Molecular Formula: C₂₅H₃₀N₂O₆
• Molecular Weight: 454.523
• Mol file: 914382-69-7.mol

Synonyms:(S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester

Chemical Property of (S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester

There total 3 articles about (S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(S)-[(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester (914382-68-6) + di-tert-butyl dicarbonate (24424-99-5) → (S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester (914382-69-7)

Guidance literature:

(S)-[(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester; di-tert-butyl dicarbonate; In dichloromethane; at 50 ℃;

With N,N',N'-trimethylenediamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

(1S)-2-(cyclopentyloxy)-2-oxo-1-phenylethanaminium 4-methylbenzenesulfonate (914604-52-7) → (S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester (914382-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 3.5 h

2.1: dichloromethane / 50 °C

2.2: 2 h / 20 °C

With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; dichloromethane;

Reference yield:

3-nitro-benzaldehyde (99-61-6) → (S)-[tert-butoxycarbonyl-(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester (914382-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 3.5 h

2.1: dichloromethane / 50 °C

2.2: 2 h / 20 °C

With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; dichloromethane;

upstream raw materials:

(S)-[(3-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester

di-tert-butyl dicarbonate

(1S)-2-(cyclopentyloxy)-2-oxo-1-phenylethanaminium 4-methylbenzenesulfonate

3-nitro-benzaldehyde

Downstream raw materials:

(S)-[tert-butoxycarbonyl-(3-{[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]-thiophen-6-ylmethyl]-amino}-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester

(S)-[(3-amino-benzyl)-tert-butoxycarbonyl-amino]-phenyl-acetic acid cyclopentyl ester