Technology Process of 4-nitrobenzyl (R)-6-hydroxyheptanoate
There total 4 articles about 4-nitrobenzyl (R)-6-hydroxyheptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
acetonitrile;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/ol302970c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate; methanol / water / 6 h / 20 °C
2: tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide; ethyl acetate / 18 h / 50 °C / Inert atmosphere
3: water; sodium hydroxide / methanol / 11 h / 60 °C / Reflux
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 20 °C / Inert atmosphere
With
methanol; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide;
In
methanol; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;
DOI:10.1021/ol302970c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; sodium hydroxide / methanol / 11 h / 60 °C / Reflux
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 20 °C / Inert atmosphere
With
water; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide;
In
methanol; acetonitrile;
DOI:10.1021/ol302970c
