1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane

Base Information

Chemical Name:1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane
CAS No.:560086-37-5
Molecular Formula:C₅₄H₅₂N₆O₁₀
Molecular Weight:945.041
Hs Code.:

Synonyms:1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane

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Chemical Property of 1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane

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Technology Process of 1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane

There total 5 articles about 1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 560086-13-7
ethyl 2-(2-nitrophenyl)-1H-benzimidazole-4-carboxylate

: 560086-33-1
1,8-bis(3-bromomethylphenoxy)octane

: 560086-37-5
1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane

Guidance literature:: ethyl 2-(2-nitrophenyl)-1H-benzimidazole-4-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

1,8-bis(3-bromomethylphenoxy)octane; In tetrahydrofuran; at 20 ℃; for 14h;
DOI:10.1021/ja030196d

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 560086-37-5
1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 12 h / 20 °C

2.1: Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

2.2: 93 percent / AcONa / acetic acid / 15 h / Heating

3.1: NaH / tetrahydrofuran / 0 - 20 °C

3.2: 92 percent / tetrahydrofuran / 14 h / 20 °C

With oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja030196d

Reference yield:

: 620-24-6
3-Hydroxybenzyl alcohol

: 560086-37-5
1,8-bis{3-[4-ethoxycarbonyl-2-(2-nitrophenyl)benzimidazol-1-ylmethyl]phenoxy}octane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / aq. NaOH / ethanol / 18 h / Heating

2.1: 74 percent / PBr₃ / CH₂Cl₂ / 21 h / 20 °C

3.1: NaH / tetrahydrofuran / 0 - 20 °C

3.2: 92 percent / tetrahydrofuran / 14 h / 20 °C

With sodium hydroxide; phosphorus tribromide; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja030196d