{2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone

Base Information

Chemical Name:{2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone
CAS No.:607708-16-7
Molecular Formula:C₂₀H₁₅Cl₂NOS
Molecular Weight:388.317
Hs Code.:

Synonyms:{2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone

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Chemical Property of {2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone

Chemical Property:

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Technology Process of {2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone

There total 5 articles about {2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 607708-13-4
{2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanol

: 607708-16-7
{2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jo0344081

Reference yield:

: 441052-91-1
2,6-dichloro-4-[(phenylthio)methyl]nicotinaldehyde

: 607708-16-7
{2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran

1.2: 73 percent / tetrahydrofuran / -78 - 0 °C

2.1: 78 percent / PCC / CH₂Cl₂ / 1.5 h / 20 °C

With magnesium; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 1.2: Grignard reaction;
DOI:10.1021/jo0344081

Reference yield:

: 441052-90-0
2,6-dichloro-4-[(phenylthio)methyl]nicotinonitrile

: 607708-16-7
{2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(4-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 62 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / -78 - 20 °C

2.1: Mg / tetrahydrofuran

2.2: 73 percent / tetrahydrofuran / -78 - 0 °C

3.1: 78 percent / PCC / CH₂Cl₂ / 1.5 h / 20 °C

With diisobutylaluminium hydride; magnesium; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene; 2.2: Grignard reaction;
DOI:10.1021/jo0344081