2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid

Base Information

• Chemical Name: 2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid
• CAS No.: 121809-91-4
• Molecular Formula: C₁₇H₁₅Cl₂NO₄
• Molecular Weight: 368.216
• Mol file: 121809-91-4.mol

Synonyms:2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid

Chemical Property of 2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid

There total 6 articles about 2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,5-dichlorobenzoyl chloride (2905-62-6) + 2-(4-aminophenoxy)-2-methyl propionic acid (117011-70-8) → 2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid (121809-91-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 1h;

DOI:10.1021/jm00130a021

Reference yield:

(4-hydroxyphenyl)carbamic acid ethyl ester (7159-95-7) → 2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid (121809-91-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 percent / NaOH / 4 h / Heating

2: 87 percent / 10percent KOH / 0.5 h / Heating

3: 78 percent / 2 N NaOH / tetrahydrofuran / 1 h

With potassium hydroxide; sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00130a021

Reference yield:

4-cyanophenol (767-00-0) → 2-(4-(3,5-dichlorobenzamido)phenoxy)-2-methylpropionic acid (121809-91-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / NaOH / a) 20 min, b) reflux, 4 h

2: 88 percent / 3percent H₂O₂, KOH / H₂O

3: 90 percent / Br₂, NaOH / H₂O / 0.5 h / 75 °C

4: 78 percent / 2 N NaOH / tetrahydrofuran / 1 h

With potassium hydroxide; sodium hydroxide; dihydrogen peroxide; bromine; In tetrahydrofuran; water;

DOI:10.1021/jm00130a021

upstream raw materials:

3,5-dichlorobenzoyl chloride

2-(4-aminophenoxy)-2-methyl propionic acid

(4-hydroxyphenyl)carbamic acid ethyl ester

4-cyanophenol