(2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Chemical Name:(2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone
CAS No.:1597519-39-5
Molecular Formula:C₂₂H₁₇F₃N₆O₃
Molecular Weight:470.411
Hs Code.:

Synonyms:(2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Chemical Property of (2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Technology Process of (2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

There total 7 articles about (2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1001401-62-2
2-(2H-1,2,3-triazol-2-yl)benzoic acid

: 1597528-48-7
5-(S)-pyrrolidin-2-yl-3-(2-trifluoromethoxyphenyl)[1,2,4]oxadiazole

: 1597519-39-5
(2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: 2-(2H-1,2,3-triazol-2-yl)benzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

5-(S)-pyrrolidin-2-yl-3-(2-trifluoromethoxyphenyl)[1,2,4]oxadiazole; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201900242

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 1597519-39-5
(2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201900242

Reference yield:

: N'-hydroxy-2-(trifluoromethoxy)benzenecarboximidamide

: 1597519-39-5
(2-[1 ,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/cmdc.201900242