N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine

Base Information

• Chemical Name: N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine
• CAS No.: 147769-98-0
• Molecular Formula: C₁₈H₂₈N₂O
• Molecular Weight: 288.433
• Mol file: 147769-98-0.mol

Synonyms:N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine

Chemical Property of N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine

There total 18 articles about N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(piperidin-1-yl)benzonitrile (72752-52-4) → N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine (147769-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; toluene / 3 h / Heating

2: 34 percent / toluene / 15 h / Ambient temperature

3: H₂, NaOH, Et₃N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH₂Cl₂ / 170 h / 30 °C / 75006 Torr

With titanium(IV) isopropylate; sodium hydroxide; hydrogen; triethylamine; Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1021/jm9810349

Reference yield:

N-acetyl-N-<3-methyl-1-(2-(1-piperidinyl)phenyl)-1-(Z)-buten-1-yl>-amine (147769-97-9) → N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine (147769-98-0) + N-[3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl]-acetamide

Guidance literature:

With titanium(IV) isopropylate; sodium hydroxide; hydrogen; triethylamine; Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; In methanol; dichloromethane; at 30 ℃; for 170h; under 75006 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jm9810349

Reference yield:

piperidine (110-89-4) → N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine (147769-98-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C

2: tetrahydrofuran; toluene / 3 h / Heating

3: 34 percent / toluene / 15 h / Ambient temperature

4: H₂, NaOH, Et₃N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH₂Cl₂ / 170 h / 30 °C / 75006 Torr

With N-Formylpiperidine; titanium(IV) isopropylate; sodium hydroxide; hydrogen; triethylamine; Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1021/jm9810349

upstream raw materials:

(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine

N-<(R)-phenyl-(2-(1-piperidinyl)phenyl)-methyl>-N-<(S')-p-toluene-sulfinyl>-amine

N-acetyl-N-<3-methyl-1-(2-(1-piperidinyl)phenyl)-1-(Z)-buten-1-yl>-amine

piperidine

Downstream raw materials:

(R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine

(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine

(R)-(-)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate

(S)-(+)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate