Technology Process of N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine
There total 18 articles about N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrahydrofuran; toluene / 3 h / Heating
2: 34 percent / toluene / 15 h / Ambient temperature
3: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr
With
titanium(IV) isopropylate; sodium hydroxide; hydrogen; triethylamine;
Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)};
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm9810349
- Guidance literature:
-
With
titanium(IV) isopropylate; sodium hydroxide; hydrogen; triethylamine;
Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)};
In
methanol; dichloromethane;
at 30 ℃;
for 170h;
under 75006 Torr;
Yield given;
Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jm9810349
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C
2: tetrahydrofuran; toluene / 3 h / Heating
3: 34 percent / toluene / 15 h / Ambient temperature
4: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr
With
N-Formylpiperidine; titanium(IV) isopropylate; sodium hydroxide; hydrogen; triethylamine;
Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)};
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm9810349
