(-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat

Base Information

• Chemical Name: (-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat
• CAS No.: 132168-56-0
• Molecular Formula: C₂₃H₂₇NO₄
• Molecular Weight: 381.472

Synonyms:(-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat

Chemical Property of (-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat

Chemical Property:

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Technology Process of (-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat

There total 3 articles about (-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,3-Dimethylacryloyl chloride (3350-78-5) + (-)-(R)-2<<(Furan-2-yl)methyl>amino>-2-phenylethanol (132168-60-6) → (-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat (132168-56-0)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1002/hlca.19900730816

Reference yield:

furfural (98-01-1) → (-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat (132168-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2) NaBH₄ / 1) toluene, reflux, 2) i-PrOH, r.t., 2h

2: 82 percent / pyridine / tetrahydrofuran / 3 h / 0 °C

With pyridine; sodium tetrahydroborate; In tetrahydrofuran;

DOI:10.1002/hlca.19900730816

Reference yield:

D-2-phenylglycinol (56613-80-0) → (-)-(R)-<2--N-(3-methylbut-2-enoyl)amino>-2-phenylethyl>-3-methyl-but-2-enoat (132168-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2) NaBH₄ / 1) toluene, reflux, 2) i-PrOH, r.t., 2h

2: 82 percent / pyridine / tetrahydrofuran / 3 h / 0 °C

With pyridine; sodium tetrahydroborate; In tetrahydrofuran;

DOI:10.1002/hlca.19900730816

upstream raw materials:

3,3-Dimethylacryloyl chloride

(-)-(R)-2<<(Furan-2-yl)methyl>amino>-2-phenylethanol

furfural

D-2-phenylglycinol

Downstream raw materials:

(-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

(+)-(3aR,4R,5R,6R,7aS,1'R)-2-(1'-Cyclohexyl-2'-hydroxyethyl)-3a,6:4,5-diepoxyperhydro-7,7-dimethyl-1H-isoindol-1-on

(-)-(1R,5S,7S)-3-[(1R)-2-hydroxy-1-phenylethyl]-6,6-dimethyl-10-oxa-3-azatricyclo[5.2.1.0^1,5]dec-8-en-4-one

(-)-(3aR,4R,5R,6R,7aS,1'R)-3a,6:4,5-Diepoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

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