N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide
CAS No.:1604803-24-8
Molecular Formula:C₁₇H₁₂ClF₃N₂O₂
Molecular Weight:368.743
Hs Code.:

Synonyms:N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide

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Chemical Property of N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide

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Technology Process of N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide

There total 7 articles about N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1604803-23-7
2-(2-chloro-6-methoxyphenyl)-1H-indol-6-ylamine

: 407-25-0
trifluoroacetic anhydride

: 1604803-24-8
N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 1h;

Reference yield:

: 99-09-2
3-nitro-aniline

: 1604803-24-8
N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 4-aminopyridine / tetrahydrofuran / 3 h / 25 °C

2.1: tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

2.2: 1 h / -70 - 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C

4.1: trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 25 °C

4.2: 3 h / 70 °C

5.1: triethyl phosphite / 3 h / Reflux

6.1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C / Reflux

7.1: triethylamine / dichloromethane / 1 h / 25 °C

With 4-aminopyridine; tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; triethyl phosphite; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1604803-46-4
{4-[2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl]-3-nitrophenyl}carbamic acid tert-butyl ester

: 1604803-24-8
N-[2-(2-chloro-6-methoxyphenyl)-1H-indol-6-yl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 25 °C

1.2: 3 h / 70 °C

2.1: triethyl phosphite / 3 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C / Reflux

4.1: triethylamine / dichloromethane / 1 h / 25 °C

With triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; triethyl phosphite; In tetrahydrofuran; dichloromethane;