(3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid

Base Information

Chemical Name:(3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid
CAS No.:104937-58-8
Molecular Formula:C₈H₁₂N₂O₃S
Molecular Weight:216.261
Hs Code.:

Synonyms:(3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid

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Chemical Property of (3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid

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Technology Process of (3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid

There total 8 articles about (3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 98303-11-8
(3S, 6S, 9R)-2-oxo-3-phthalimido-7-thia-1-azabicyclo<4.3.0>nonane-9-carboxylic acid

: 104937-58-8
(3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid

Guidance literature:: With hydrazine hydrate; In ethanol; chloroform; for 24h; Ambient temperature;
DOI:10.1021/ja9608757

Reference yield:

: (3R,6S,8aS)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-oxo-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid ethyl ester

: 104937-58-8
(3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / aq. HCl, AcOH / 1.5 h / Heating

2: 96 percent / N₂H₄*H₂O / CHCl₃; ethanol / 24 h / Ambient temperature

With hydrogenchloride; hydrazine hydrate; acetic acid; In ethanol; chloroform;
DOI:10.1021/ja9608757

Reference yield:

: 77603-47-5
α-Methyl N-phthalyl-L-glutamate γ-aldehyde

: 104937-58-8
(3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / NaOAc / ethanol; H₂O / 8 h / Ambient temperature

2: 80 percent / dimethylformamide / 90 °C

3: 85 percent / N₂H₄*H₂O / ethanol / 1 h / Heating

With sodium acetate; hydrazine hydrate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)90216-9