Technology Process of 2H-1-Benzopyran,3,4-dihydro-2-(2-methylphenyl)-(9CI)
There total 11 articles about 2H-1-Benzopyran,3,4-dihydro-2-(2-methylphenyl)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate; toluene-4-sulfonic acid hydrazide;
In
1,4-dioxane;
at 110 ℃;
for 24h;
regioselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2015.08.027
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
DOI:10.1055/s-0030-1260564
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydride; sodium iodide / N,N-dimethyl-formamide
2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 °C
3: sodium hydride / tetrahydrofuran / 16 h / 20 °C
4: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0.17 h / 60 °C
5: acetic acid / water / 16 h
6: palladium 10% on activated carbon; hydrogen / ethyl acetate
With
sodium tetrahydroborate; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; sodium iodide;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
2: Swern oxidation / 3: Claisen Schmidt condensation;
DOI:10.1055/s-0030-1260564
