(1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol

Base Information

Chemical Name:(1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol
CAS No.:884653-87-6
Molecular Formula:C₂₅H₂₄ClN₅O₃
Molecular Weight:477.95
Hs Code.:

Synonyms:(1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol

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Chemical Property of (1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol

Chemical Property:

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Technology Process of (1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol

There total 4 articles about (1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60176-77-4
(1S,4R)-4-hydroxy-2-cyclopentenyl acetate

: 884653-87-6
(1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol

Guidance literature:: bis-[(4-methoxy-phenyl)-methyl]-(2-chloro-9H-purin-6-yl)-amine; With sodium hydride; In THF (tetrahydrofuran), deoxygenated; dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h;

(1S,4R)-4-hydroxy-2-cyclopentenyl acetate; With triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dimethyl sulfoxide; at 50 ℃; for 2h;

Reference yield:

: bis-[(4-methoxy-phenyl)-methyl]-(2-chloro-9H-purin-6-yl)-amine

: 60410-16-4
(1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate

: 884653-87-6
(1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol

Guidance literature:: bis-[(4-methoxy-phenyl)-methyl]-(2-chloro-9H-purin-6-yl)-amine; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h;

(1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; at 50 ℃; for 2h;

Reference yield:

: 884653-86-5
[bis-(4-methoxy-phenyl)-methyl]-(2-chloro-9H-purin-6-yl)-amine

: 60410-16-4
(1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate

: 884653-87-6
(1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; at 50 ℃; for 2h;
DOI:10.1016/j.bmcl.2009.11.131