Technology Process of tert-butyl (5S,6S,9R)-6-(2,3-difluorophenyl)-9-(1,3-dioxoisoindolin-2-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ylcarbamate
There total 8 articles about tert-butyl (5S,6S,9R)-6-(2,3-difluorophenyl)-9-(1,3-dioxoisoindolin-2-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
dichloromethane;
at 0 - 20 ℃;
for 72h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: N-chloro-succinimide; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
2: sodium azide / N,N-dimethyl-formamide / 17.5 h / 20 - 50 °C / Inert atmosphere
3: hydrogen / palladium 10% on activated carbon / ethanol / 7.5 h / 760.05 Torr
4: tetrahydrofuran / 20 °C
5: N-butyl-N,N-dipropylbutan-1-aminium fluoride / tetrahydrofuran / 1 h / 20 °C
6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
7: water; lithium hydroxide / tetrahydrofuran / 5 h / 20 °C
8: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 72 h / 0 - 20 °C
With
N-chloro-succinimide; sodium azide; di-isopropyl azodicarboxylate; N-butyl-N,N-dipropylbutan-1-aminium fluoride; water; hydrogen; triphenylphosphine; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
6: Mitsunobu reaction / 8: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium azide / N,N-dimethyl-formamide / 17.5 h / 20 - 50 °C / Inert atmosphere
2: hydrogen / palladium 10% on activated carbon / ethanol / 7.5 h / 760.05 Torr
3: tetrahydrofuran / 20 °C
4: N-butyl-N,N-dipropylbutan-1-aminium fluoride / tetrahydrofuran / 1 h / 20 °C
5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
6: water; lithium hydroxide / tetrahydrofuran / 5 h / 20 °C
7: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 72 h / 0 - 20 °C
With
sodium azide; di-isopropyl azodicarboxylate; N-butyl-N,N-dipropylbutan-1-aminium fluoride; water; hydrogen; triphenylphosphine; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
5: Mitsunobu reaction / 7: Mitsunobu reaction;
