di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate

Base Information

Chemical Name:di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate
CAS No.:1357103-85-5
Molecular Formula:C₂₉H₃₇FN₅O₇P
Molecular Weight:617.614
Hs Code.:

Synonyms:di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate

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Chemical Property of di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate

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Technology Process of di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate

There total 4 articles about di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one trifluoroacetate

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: 1357103-85-5
di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate

Guidance literature:: 5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one trifluoroacetate; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h; Inert atmosphere;

di-tert-butyl chloromethyl phosphate; In N,N-dimethyl-formamide; at 20 ℃; for 49h; Inert atmosphere;

Reference yield:

: 14733-77-8
5-amino-2-benzoxazolinone

: 1357103-85-5
di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; methanol / 64 h / 20 °C

2.1: isopropyl alcohol / 22 h / 75 - 80 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

3.2: 49 h / 20 °C / Inert atmosphere

With caesium carbonate; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1780-31-0
2,6-dichloro-5-methylpyrimidine

: 1357103-85-5
di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; methanol / 64 h / 20 °C

2.1: isopropyl alcohol / 22 h / 75 - 80 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

3.2: 49 h / 20 °C / Inert atmosphere

With caesium carbonate; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;