methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate

Base Information

Chemical Name:methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate
CAS No.:1380316-21-1
Molecular Formula:C₂₄H₄₀N₂O₇Si
Molecular Weight:496.676
Hs Code.:

Synonyms:methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate

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Chemical Property of methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate

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Technology Process of methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate

There total 3 articles about methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1380316-20-0
(4-bromo-3-nitrophenoxy)(triisopropyl)silane

: 93267-04-0,170848-34-7,889670-02-4
N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

: 1380316-21-1
methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate

Guidance literature:: N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester; With zinc; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 0.5h; Cooling; Inert atmosphere;

(4-bromo-3-nitrophenoxy)(triisopropyl)silane; With XPhos; palladium diacetate; In N,N-dimethyl-formamide; at 40 ℃; for 18h; Cooling; Inert atmosphere;

Reference yield:

: 78137-76-5
4-bromo-3-nitrophenol

: 1380316-21-1
methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 18 °C

2.1: zinc / N,N-dimethyl-formamide / 0.5 h / 20 - 25 °C / Cooling; Inert atmosphere

2.2: 18 h / 40 °C / Cooling; Inert atmosphere

With 1H-imidazole; zinc; In N,N-dimethyl-formamide;

Reference yield:

: 5344-78-5
4-bromo-3-nitroanizole

: 1380316-21-1
methyl N-(tert-butoxycarbonyl)-2-nitro-O-(triisopropylsilyl)-L-tyrosinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / 50 h / -78 - 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 18 °C

3.1: zinc / N,N-dimethyl-formamide / 0.5 h / 20 - 25 °C / Cooling; Inert atmosphere

3.2: 18 h / 40 °C / Cooling; Inert atmosphere

With 1H-imidazole; boron tribromide; zinc; In dichloromethane; N,N-dimethyl-formamide;