[5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone

Base Information

Chemical Name:[5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone
CAS No.:1322047-91-5
Molecular Formula:C₂₇H₂₃Cl₄N₃O
Molecular Weight:547.311
Hs Code.:

Synonyms:[5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone

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Chemical Property of [5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone

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Technology Process of [5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone

There total 10 articles about [5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 637362-32-4
(2-chloro-4-pyridyl)-(5-chlorospiro[indoline-3,4'-piperidine]-1-yl)methanone

: 1322049-15-9
1-[(E)-3-bromoprop-1-enyl]-2,3-dichloro-benzene

: 1322047-91-5
[5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone

Guidance literature:: (2-chloro-4-pyridyl)-(5-chlorospiro[indoline-3,4'-piperidine]-1-yl)methanone; With polymer-supported 2-tert- butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP); In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

1-[(E)-3-bromoprop-1-enyl]-2,3-dichloro-benzene; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

: 20595-44-2
3-(2,3-dichlorophenyl)acrylic acid

: 1322047-91-5
[5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: carbon tetrabromide / dichloromethane / 1 h / 20 °C

3.1: polymer-supported 2-tert- butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) / N,N-dimethyl-formamide / 0.5 h / 60 °C

3.2: 100 °C

With carbon tetrabromide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 65287-34-5
2-chloropyridine-4-carbonyl chloride

: 1322047-91-5
[5-chloro-1'-[(E)-3-(2,3-dichlorophenyl)allyl]spiro[indoline-3,4'-piperidine]-1-yl]-(2-chloro-4-pyridyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: 2 h / Cooling with ice

3.1: polymer-supported 2-tert- butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) / N,N-dimethyl-formamide / 0.5 h / 60 °C

3.2: 100 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;