Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

Base Information

Chemical Name:Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate
CAS No.:163275-44-3
Molecular Formula:C₂₁H₃₆O₅Si
Molecular Weight:396.599
Hs Code.:

Synonyms:Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

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Technology Process of Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

There total 2 articles about Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 547-63-7,133320-07-7,67505-84-4
Methyl isobutyrate

: 163275-51-2
(2S)-2-benzyloxy-3-[tert-butyl(dimethyl)silyloxy]-propanal

: 163275-44-3
Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

: Methyl (3S,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

Guidance literature:: Methyl isobutyrate; With lithium diisopropyl amide; In diethyl ether; at -78 ℃; for 0.5h;

(2S)-2-benzyloxy-3-[tert-butyl(dimethyl)silyloxy]-propanal; In diethyl ether; at -78 ℃; for 1h;
DOI:10.1002/(sici)1521-3765(19990104)5:1<121::aid-chem121>3.3.co;2-f

Reference yield:

: 547-63-7,133320-07-7,67505-84-4
Methyl isobutyrate

: 163275-51-2
(2S)-2-benzyloxy-3-[tert-butyl(dimethyl)silyloxy]-propanal

: 163275-44-3
Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

Guidance literature:: With lithium diisopropyl amide; In diethyl ether; at -78 ℃; Yield given;
DOI:10.1246/cl.1995.179

Reference yield: 75.0%

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 163275-44-3
Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,2-dimethylpentanoate

: Methyl (3R,4S)-4-benzyloxy-5-(tert-butyldimethylsiloxy)-3-(p-methoxybenzyloxy)-2,2-dimethylpentanoate

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1002/(sici)1521-3765(19990104)5:1<121::aid-chem121>3.3.co;2-f