2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile

Base Information

Chemical Name:2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile
CAS No.:1378014-63-1
Molecular Formula:C₂₂H₁₇N₃O₃
Molecular Weight:371.395
Hs Code.:

Synonyms:2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile

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Chemical Property of 2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile

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Technology Process of 2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile

There total 3 articles about 2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 2700-22-3
Benzylidenemalononitrile

: C₁₂H₁₁NO₃

: 1378014-63-1
2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile

Guidance literature:: With piperidine; In ethanol; water; at 20 ℃; for 26h;
DOI:10.1021/jm300345z

Reference yield:

: 1378014-72-2
ethyl 2-(N-(2-oxopropyl)benzamido)acetate

: 1378014-63-1
2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 20 h / 0 °C / Inert atmosphere

2: piperidine / ethanol; water / 26 h / 20 °C

With piperidine; potassium tert-butylate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm300345z

Reference yield:

: 15057-40-6
ethyl 2-(benzyl(2-oxopropyl)amino)acetate

: 1378014-63-1
2-amino-7-benzoyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; palladium on activated charcoal; hydrogen / ethanol / 2 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 14 h / 0 - 20 °C / Inert atmosphere

3: potassium tert-butylate / tetrahydrofuran / 20 h / 0 °C / Inert atmosphere

4: piperidine / ethanol; water / 26 h / 20 °C

With piperidine; hydrogenchloride; palladium on activated charcoal; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm300345z