N-Phenyl-2-quinolinecarboxamide

Base Information

• Chemical Name: N-Phenyl-2-quinolinecarboxamide
• CAS No.: 7477-46-5
• Molecular Formula: C16H12 N2 O
• Molecular Weight: 248.284
• Hs Code.: 2933499090
• Mol file: 7477-46-5.mol

Synonyms:Quinaldanilide(8CI); N-Phenylquinoline-2-carboxamide; NSC 400841

Chemical Property of N-Phenyl-2-quinolinecarboxamide

Chemical Property:

• Vapor Pressure: 3.17E-05mmHg at 25°C
• Boiling Point: 355.3°C at 760 mmHg
• Flash Point: 168.7°C
• PSA: 41.99000
• Density: 1.269g/cm³
• LogP: 3.56010

Purity/Quality:

99% ^*data from raw suppliers

N-PHENYLQUINOLINE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Phenyl-2-quinolinecarboxamide

There total 14 articles about N-Phenyl-2-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(E)-N-(quinolin-2-ylmethylene)aniline (5603-13-4) → N-phenylquinoline-2-carboxamide (7477-46-5)

Guidance literature:

With copper(l) iodide; oxygen; Trimethylacetic acid; at 120 ℃; for 48h;

DOI:10.1039/c5ob00915d

Reference yield: 81.0%

N-(quinolin-2-ylmethylidene)aniline (5603-13-4) + aniline (62-53-3) → N-phenylquinoline-2-carboxamide (7477-46-5)

Guidance literature:

With copper(l) iodide; oxygen; In water; at 130 ℃; for 24h; Reagent/catalyst;

DOI:10.1039/c5ob00685f

Reference yield: 80.0%

quinoline-2-carboxylic acid (93-10-7,1199266-78-8) + aniline (62-53-3) → N-phenylquinoline-2-carboxamide (7477-46-5)

Guidance literature:

quinoline-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

aniline; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.6b00004

upstream raw materials:

quinolin-2-ylcarbonyl chloride

aniline

quinoline-2-carboxylic acid-anhydride

quinoline-2-carboxylic acid

Downstream raw materials:

N-(2-(trifluoromethyl)phenyl)quinoline-2-carboxamide