7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
• CAS No.: 73075-45-3
• Molecular Formula: C₉H₁₀ClN*ClH
• Molecular Weight: 204.099
• Hs Code.: 2933499090
• Mol file: 73075-45-3.mol

Synonyms:Isoquinoline,7-chloro-1,2,3,4-tetrahydro-, hydrochloride (9CI);7-Chloro-1,2,3,4-tetrahydroisoquinolinehydrochloride;

Chemical Property of 7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 213-214.5 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• PSA: 12.03000
• LogP: 3.11650
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-Chloro-1,2,3,4-tetrahydroisoquinolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

There total 1 articles about 7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-1,2,3,4-tetrahydro-isoquinoline (82771-60-6) → 7-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride (73075-45-3)

Guidance literature:

With hydrogenchloride; In Isopropyl acetate; toluene;

DOI:10.1016/j.tet.2018.10.016

Reference yield:

7-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride (73075-45-3) → 7-chloro-3,4-dihydroisoquinoline (60518-41-4)

Guidance literature:

7-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride; With sodium hydroxide; In water; at 23 ℃; for 0.75h; Inert atmosphere;

With N-Bromosuccinimide; In dichloromethane; at 23 ℃; for 1h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water; at 23 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03886 DOI:10.1021/acs.orglett.8b03886

upstream raw materials:

7-chloro-1,2,3,4-tetrahydro-isoquinoline

Downstream raw materials:

7-chloro-3,4-dihydroisoquinoline

Refernces