1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene

Base Information

Chemical Name:1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene
CAS No.:183559-14-0
Molecular Formula:C₄₈H₅₇BrO₄Si₂
Molecular Weight:834.053
Hs Code.:

Synonyms:1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene

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Chemical Property of 1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene

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Technology Process of 1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene

There total 5 articles about 1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 183559-13-9
(2S,4R)-1-Bromo-8-(4-methoxy-benzyloxy)-oct-6-yne-2,4-diol

: 183559-14-0
1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene

Guidance literature:: With 1H-imidazole; dmap; In diethyl ether; dichloromethane; for 12h;
DOI:10.1016/0040-4039(96)01700-5

Reference yield:

: 109905-51-3
(2S,4S)-1,2:4,5-dianhydro-3-deoxypentitol

: 183559-14-0
1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 °C

2: 91 percent / Li₂NiBr₄ / tetrahydrofuran / 2.5 h / Ambient temperature

3: 80 percent / imidazole, DMAP / CH₂Cl₂; diethyl ether / 12 h

With 1H-imidazole; dmap; dilithium tetrabromonickelate(II); boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/0040-4039(96)01700-5

Reference yield:

: 136030-29-0
(2S,4S)-1,5-dichloro-2,4-pentanediol

: 183559-14-0
1-[(5R,7S)-8-Bromo-5,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-2-ynyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / KOH / diethyl ether / 2 h / Ambient temperature

2: 53 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 °C

3: 91 percent / Li₂NiBr₄ / tetrahydrofuran / 2.5 h / Ambient temperature

4: 80 percent / imidazole, DMAP / CH₂Cl₂; diethyl ether / 12 h

With 1H-imidazole; dmap; potassium hydroxide; dilithium tetrabromonickelate(II); boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/0040-4039(96)01700-5