Technology Process of (-)-(5S)-2,5,6,6-tetramethylcyclohex-1-ene-1-carbonyl chloride
There total 8 articles about (-)-(5S)-2,5,6,6-tetramethylcyclohex-1-ene-1-carbonyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent / NaOH / dimethylsulfoxide / Ambient temperature
2: 1.) SnCl4, 2.) LiAlH4 / 1.) toluene, 0 deg C, 20 min; 2.) Et2O, room temp. 1 h
3: 1.) oxalyl chloride/DMSO, 2.) Et3N / 1.) CH2Cl2, -70 deg, 15 min; 2.) CH2Cl2, room temp., 30 min
4: EtONa / ethanol / Ambient temperature
5: 65 percent / O2 / diethyl ether / 56 h
6: 83 percent / oxalyl chloride / toluene / 12 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; oxygen; sodium ethanolate; tin(IV) chloride; dimethyl sulfoxide; triethylamine;
In
diethyl ether; ethanol; dimethyl sulfoxide; toluene;
DOI:10.1002/hlca.19930760521
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) SnCl4, 2.) LiAlH4 / 1.) toluene, 0 deg C, 20 min; 2.) Et2O, room temp. 1 h
2: 1.) oxalyl chloride/DMSO, 2.) Et3N / 1.) CH2Cl2, -70 deg, 15 min; 2.) CH2Cl2, room temp., 30 min
3: EtONa / ethanol / Ambient temperature
4: 65 percent / O2 / diethyl ether / 56 h
5: 83 percent / oxalyl chloride / toluene / 12 h / Ambient temperature
With
lithium aluminium tetrahydride; oxalyl dichloride; oxygen; sodium ethanolate; tin(IV) chloride; dimethyl sulfoxide; triethylamine;
In
diethyl ether; ethanol; toluene;
DOI:10.1002/hlca.19930760521
