(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

Base Information

Chemical Name:(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide
CAS No.:1326280-96-9
Molecular Formula:C₁₇H₂₆ClN₅O
Molecular Weight:351.879
Hs Code.:

Synonyms:(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

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Chemical Property of (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

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Technology Process of (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

There total 2 articles about (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1326280-45-8
N-((3-chloropyrazin-2-yl)methyl)-4-oxocyclohexane-1-carboxamide

: 1326280-96-9
(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

: 1326280-94-7
(cis)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

Guidance literature:: 1-methyl-piperazine; N-((3-chloropyrazin-2-yl)methyl)-4-oxocyclohexane-1-carboxamide; With sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 874-61-3
4-oxocyclohexanecarboxylic acid

: 1326280-96-9
(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

: 1326280-94-7
(cis)-N-((3-chloropyrazin-2-yl)methyl)-4-(4-methylpiperazin-1-yl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / dichloromethane / 16 h / 20 °C

2: sodium cyanoborohydride; acetic acid / dichloromethane / 16 h / 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; HATU; In dichloromethane;