methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

Base Information

Chemical Name:methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate
CAS No.:440641-00-9
Molecular Formula:C₃₃H₃₄O₈Si
Molecular Weight:586.714
Hs Code.:

Synonyms:methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

Suppliers and Price of methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

There total 6 articles about methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 440641-85-0
methyl (2S,3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-hydroxybutanoate

: 440641-00-9
methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1021/jo011157s

Reference yield:

: 13171-64-7
Dimethyl D-tartrate

: 440641-00-9
methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 62 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h

2.1: BH₃*SMe₂ / tetrahydrofuran / 2 h / 20 °C

2.2: NaBH₄ / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: 1.30 g / imidazole / CH₂Cl₂ / 1 h / 0 °C

4.1: 87 percent / dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 20 °C

5.1: 88 percent / Me₂AlCl / CH₂Cl₂; various solvent(s) / 4 h / -25 - 20 °C

6.1: 96 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.25 h / 20 °C

With 1H-imidazole; dmap; dimethylsulfide borane complex; dimethylaluminum chloride; pyridinium p-toluenesulfonate; Dess-Martin periodane; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 6.1: Dess-Martin oxidation;
DOI:10.1021/jo011157s

Reference yield:

: 93499-95-7,102573-08-0
(2S,3R)-3,4-Dihydroxy-2-(tetrahydro-pyran-2-yloxy)-butyric acid methyl ester

: 440641-00-9
methyl (3R)-4-tert-butyldiphenylsiloxy-3-(5-(4-methylphenoxy)-2-furoyloxy)-2-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.30 g / imidazole / CH₂Cl₂ / 1 h / 0 °C

2: 87 percent / dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 20 °C

3: 88 percent / Me₂AlCl / CH₂Cl₂; various solvent(s) / 4 h / -25 - 20 °C

4: 96 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.25 h / 20 °C

With 1H-imidazole; dmap; dimethylaluminum chloride; Dess-Martin periodane; dicyclohexyl-carbodiimide; In dichloromethane; 4: Dess-Martin oxidation;
DOI:10.1021/jo011157s