(R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester

Base Information

Chemical Name:(R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester
CAS No.:136084-08-7
Molecular Formula:C₂₈H₃₇NO₃
Molecular Weight:435.607
Hs Code.:

Synonyms:(R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester

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Chemical Property of (R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester

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Technology Process of (R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester

There total 4 articles about (R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 25137-01-3
(R)-ethyl nipecotate

: 136059-54-6
3-((-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propanol

: 136084-08-7
(R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester

Guidance literature:: With n-butyllithium; potassium iodide; potassium carbonate; In n-heptane; ethyl acetate; acetone; toluene;

Reference yield:

: 25137-01-3
(R)-ethyl nipecotate

: toluene-4-sulfonic acid 3-(3,3-di-o-tolyl-allyloxy)-propyl ester

: 136084-08-7
(R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; hexane; at 75 ℃; for 12h;
DOI:10.1021/jm980492e

Reference yield:

: 3-Bromo-1,1-bis(2-methyl-phenyl)-1-propene

: 136084-08-7
(R)-1-(3-((1,1-bis(2-methylphenyl)-1-propen-3-yl)oxy)-1-propyl)-3-piperidinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / hexane / 0.5 h / 20 °C

1.2: 31 percent / hexane / 36 h / 75 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / 20 °C

2.2: hexane; tetrahydrofuran / 1.5 h / 20 °C

3.1: K₂CO₃ / hexane; tetrahydrofuran / 12 h / 75 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; 1.1: Metallation / 1.2: Etherification / 2.1: Metallation / 2.2: Tosylation / 3.1: Condensation;
DOI:10.1021/jm980492e