2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide

Base Information

• Chemical Name: 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide
• CAS No.: 936756-72-8
• Molecular Formula: C₃₂H₃₄FNO₅
• Molecular Weight: 531.624

Synonyms:2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide

Chemical Property of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide

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Technology Process of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide

There total 1 articles about 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.6%

2-benzylidine-4-methyl-3-oxo-pentanoic acid [4-(tetrahydro-pyran-2-yloxymethyl)phenyl]amide (936756-71-7) + 4-fluorobenzaldehyde (459-57-4) → 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide (936756-72-8)

Guidance literature:

With triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; at 90 ℃; for 6h; Heating / reflux;

Reference yield: 34.6%

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid [4-tetrahydropyran-2-yloxy-methyl-phenyl]amide (936756-72-8) + tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (125971-86-0,125995-13-3) → [(4R,6R)-6-(2-{2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-(tetrahydropyran-2-yl-oxymethyl)phenylamino)carbonyl]pyrrol-1-yl}ethyl)-2,2-dimethyl-[1,3]-dioxan-4-yl]-acetic acid tert-butyl ester (936756-73-9)

Guidance literature:

With Trimethylacetic acid; In tetrahydrofuran; n-heptane; toluene; Heating / reflux;

upstream raw materials:

2-benzylidine-4-methyl-3-oxo-pentanoic acid [4-(tetrahydro-pyran-2-yloxymethyl)phenyl]amide

4-fluorobenzaldehyde

Downstream raw materials:

[(4R,6R)-6-(2-{2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-(tetrahydropyran-2-yl-oxymethyl)phenylamino)carbonyl]pyrrol-1-yl}ethyl)-2,2-dimethyl-[1,3]-dioxan-4-yl]-acetic acid tert-butyl ester

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