(2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid

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Chemical Name:(2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid
CAS No.:848044-13-3
Molecular Formula:C₃₅H₃₉ClN₂O₈
Molecular Weight:651.156
Hs Code.:

Synonyms:(2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid

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Chemical Property of (2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid

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Technology Process of (2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid

There total 6 articles about (2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 848044-27-9
tert-butyl (2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoate

: 848044-13-3
(2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 3h;
DOI:10.1002/ejoc.200400558

Reference yield:

: 3069-52-1
(2S)-2-hydroxy-4-methylpentanoic acid 1,1-dimethylethyl ester

: 848044-13-3
(2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DCC; DMAP / CH₂Cl₂ / 5.5 h / 0 - 23 °C

2: 67 percent / diethylamine / tetrahydrofuran / 12 h / 0 - 23 °C

3: 84 percent / HOBt; DCC / tetrahydrofuran / 7 h / 23 °C

4: 79 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 23 °C

With dmap; benzotriazol-1-ol; diethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.200400558

Reference yield:

: 1027246-51-0
tert-butyl (2S)-2-{[(2R)-3-amino-2-methylpropanoyl]oxy}-4-methylpentanoate

: 848044-13-3
(2S)-2-{[(2R)-3-({3-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-D-tyrosyl}amino)-2-methylpropanoyl]oxy}-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / HOBt; DCC / tetrahydrofuran / 7 h / 23 °C

2: 79 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 23 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.200400558