2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine

Base Information

Chemical Name:2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine
CAS No.:1417917-78-2
Molecular Formula:C₁₉H₂₆N₄O₃
Molecular Weight:358.44
Hs Code.:

Synonyms:2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine

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Chemical Property of 2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine

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Technology Process of 2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine

There total 5 articles about 2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1417917-74-8
2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetonitrile

: 1417917-78-2
2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine

Guidance literature:: 2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetonitrile; With sodium methylate; In methanol; at 20 ℃; for 2h;

With ammonium chloride; In methanol; at 20 ℃; for 16h;

Reference yield:

: 76362-12-4
4-(4-methoxybenzoyl)-piperidine

: 1417917-78-2
2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 18 h / 85 °C

2.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 70 °C

3.1: sodium methylate / methanol / 2 h / 20 °C

3.2: 16 h / 20 °C

With sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1417917-67-9
3-[4-(4-methoxybenzoyl)piperidin-1-yl]pyrrolidin-2-one

: 1417917-78-2
2-{3-[4-(4-methoxybenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 70 °C

2.1: sodium methylate / methanol / 2 h / 20 °C

2.2: 16 h / 20 °C

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;