D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester

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Chemical Name:D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester
CAS No.:857080-08-1
Molecular Formula:C₃₁H₃₄N₂O₆S
Molecular Weight:562.687
Hs Code.:

Synonyms:D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester

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Chemical Property of D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester

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Technology Process of D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester

There total 5 articles about D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 857080-07-0
benzofuran-2-carboxylic acid methyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]amide

: 779341-90-1
(R)-2-(4-bromobenzenesulfonylamino)-3-methylbutyric acid tert-butyl ester

: 857080-08-1
D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 8h;
DOI:10.1016/j.bmc.2005.07.076

Reference yield: 77.0%

: 857080-08-1
D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester

Guidance literature:

Reference yield:

: 857078-25-2
benzofuran-2-carboxylic acid [4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]amide

: 857080-08-1
D-2-{4'-[(benzofuran-2-carbonyl)methylamino]biphenyl-4-sulfonylamino}-3-methylbutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / NaH / dimethylformamide; various solvent(s) / 12 h

2: 77 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 8 h / 90 °C

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2005.07.076