1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane

Base Information

Chemical Name:1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane
CAS No.:340011-20-3
Molecular Formula:C₂₈H₃₇N₃O₄Si
Molecular Weight:507.705
Hs Code.:

Synonyms:1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane

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Chemical Property of 1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane

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Technology Process of 1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane

There total 6 articles about 1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 100-51-6,185532-71-2
benzyl alcohol

: 1-{3-[(tert-butyldimethylsilyl)oxy]propyl}-2-(m-tolyl)pyrimidin-6(1H)-one-5-carboxylic acid

: 340011-20-3
1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In 1,4-dioxane; for 14h; Heating;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 340011-20-3
1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / 2,6-lutidine / CH₂Cl₂ / 5 h / 0 - 20 °C

2: 53 percent / LiI / pyridine / 10 h / Heating

3: 61 percent / Et₃N; diphenylphosphoryl azide / dioxane / 14 h / Heating

With 2,6-dimethylpyridine; diphenylphosphoranyl azide; triethylamine; lithium iodide; In 1,4-dioxane; pyridine; dichloromethane; 1: silylation / 2: hydrolysis / 3: decarboxylation; amination; condensation;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield:

: 54998-35-5
ethyl 3-methylbenzimidate hydrochloride

: 340011-20-3
1-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-3-[(tert-butyldimethylsilyl)oxy]propane

Guidance literature:: Multi-step reaction with 5 steps

1: 17.1 g / ethanol / 16 h / 20 °C

2: 99 percent / ethanol / 3 h / 90 °C

3: 94 percent / 2,6-lutidine / CH₂Cl₂ / 5 h / 0 - 20 °C

4: 53 percent / LiI / pyridine / 10 h / Heating

5: 61 percent / Et₃N; diphenylphosphoryl azide / dioxane / 14 h / Heating

With 2,6-dimethylpyridine; diphenylphosphoranyl azide; triethylamine; lithium iodide; In 1,4-dioxane; pyridine; ethanol; dichloromethane; 1: substitution / 2: cyclocondensation / 3: silylation / 4: hydrolysis / 5: decarboxylation; amination; condensation;
DOI:10.1016/S0968-0896(00)00244-3