{(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

Base Information

Chemical Name:{(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester
CAS No.:197903-05-2
Molecular Formula:C₃₁H₃₅N₃O₅
Molecular Weight:529.636
Hs Code.:

Synonyms:{(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

Suppliers and Price of {(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

There total 2 articles about {(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.3%

: C₁₀H₁₅NO*C₁₇H₁₉NO₃

: 86499-52-7
(S)-3-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one

: 197903-05-2
{(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 96866-14-7
2-(R,S)-benzyl-3-benzyloxyamino-propionic acid

: 197903-05-2
{(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (1R,2S)-ephedrine / acetonitrile

2: EDAC; HOBT / CH₂Cl₂

With ephedrine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile; 1: racemate resolution / 2: Condensation;
DOI:10.1016/S0960-894X(99)00671-X

Reference yield:

: 197903-05-2
{(S)-3-[(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid ethyl ester

: [(S)-3-((R)-2-Benzyl-3-hydroxyamino-4-oxo-butyrylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Ac₂O / tetrahydrofuran / 0 °C

2: H₂ / 10 percent Pd/C / methanol

3: aq. NaOH / methanol

With sodium hydroxide; hydrogen; acetic anhydride; palladium on activated charcoal; In tetrahydrofuran; methanol; 1: Formylation / 2: Hydrogenolysis / 3: saponification;
DOI:10.1016/S0960-894X(99)00671-X