17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol

Base Information

Chemical Name:17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol
CAS No.:473702-25-9
Molecular Formula:C₁₉H₂₃F₃N₂O
Molecular Weight:352.4
Hs Code.:

Synonyms:17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol

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Chemical Property of 17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol

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Technology Process of 17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol

There total 5 articles about 17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 473702-27-1
8β-tert-butyldimethylsilyloxy-17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstane

: 473702-25-9
17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol

Guidance literature:: With hydrogen fluoride; water; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1002/1099-0690(200208)2002:15<2529::AID-EJOC2529>3.0.CO;2-2

Reference yield:

: 473702-22-6
8β-tert-butyldimethylsilyloxy-17-{1-[3-(2,2,2-trifluoroacetyl)phenyl]methylidene}de-A,B-androstane

: 473702-25-9
17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / hydroxylamine hydrochloride / pyridine; ethanol / 4 h / Heating

2: 91 percent / Et₃N; DMAP / CH₂Cl₂ / 0.75 h / 20 °C

3: 99 percent / NH₃ / diethyl ether / 2 h / -78 °C

4: 99 percent / HF; water / acetonitrile / 2 h / 20 °C

With dmap; hydrogen fluoride; hydroxylamine hydrochloride; ammonia; water; triethylamine; In pyridine; diethyl ether; ethanol; dichloromethane; acetonitrile;
DOI:10.1002/1099-0690(200208)2002:15<2529::AID-EJOC2529>3.0.CO;2-2

Reference yield:

: 473702-26-0
8β-tert-butyldimethylsilyloxy-17(Z)-{1-[3-(2,2,2-trifluoro-1-hydroxyiminoethyl)phenyl]methylidene}de-A,B-androstane

: 473702-25-9
17(Z)-{1-[3-[(trifluoromethyl)-1,2-diaziran-3-yl]phenyl]methylidene}de-A,B-androstan-8β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Et₃N; DMAP / CH₂Cl₂ / 0.75 h / 20 °C

2: 99 percent / NH₃ / diethyl ether / 2 h / -78 °C

3: 99 percent / HF; water / acetonitrile / 2 h / 20 °C

With dmap; hydrogen fluoride; ammonia; water; triethylamine; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1002/1099-0690(200208)2002:15<2529::AID-EJOC2529>3.0.CO;2-2