N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine

Base Information

• Chemical Name: N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine
• CAS No.: 127988-32-3
• Molecular Formula: C₁₆H₁₃N₅O₂
• Molecular Weight: 307.312
• Mol file: 127988-32-3.mol

Synonyms:N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine

Chemical Property of N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine

There total 4 articles about N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-nitrobenzaldehdye (555-16-8) + 4-(1H-1,2,4-triazol-1-ylmethyl)aniline (119192-10-8) → N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine (127988-32-3)

Guidance literature:

With acetic acid; In ethanol; at 65 - 70 ℃; for 6h;

DOI:10.1016/j.molliq.2015.12.050

Reference yield:

1-(4-nitrophenyl)methyl-1,2,4-triazole (119192-09-5) → N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine (127988-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / H₂ / 10percent Pd-C / ethyl acetate / 60 °C / 760 Torr

2: 58 percent / ethanol; benzene / 24 h / Heating

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; benzene;

DOI:10.1016/0223-5234(89)90059-7

Reference yield:

4-amino-1-(4-nitrobenzyl)-1,2,4-triazolium bromide (6085-99-0) → N-(4-nitrobenzal)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine (127988-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / 10percent aq NaNO₂ / aq. HCl / 0 °C

2: 80 percent / H₂ / 10percent Pd-C / ethyl acetate / 60 °C / 760 Torr

3: 58 percent / ethanol; benzene / 24 h / Heating

With hydrogen; sodium nitrite; palladium on activated charcoal; In hydrogenchloride; ethanol; ethyl acetate; benzene;

DOI:10.1016/0223-5234(89)90059-7

upstream raw materials:

4-nitrobenzaldehdye

4-(1H-1,2,4-triazol-1-ylmethyl)aniline

1-(4-nitrophenyl)methyl-1,2,4-triazole

4-amino-1-(4-nitrobenzyl)-1,2,4-triazolium bromide

Downstream raw materials:

N-(4-nitrobenzyl)-4-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine