(1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester

Base Information

• Chemical Name: (1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester
• CAS No.: 116404-34-3
• Molecular Formula: C₂₉H₃₄BrNO₃
• Molecular Weight: 524.498
• Mol file: 116404-34-3.mol

Synonyms:(1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester

Chemical Property of (1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester

There total 2 articles about (1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

para-bromophenacyl bromide (99-73-0,132309-76-3) + ((1S,4R)-1,8-Diethyl-4-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-acetic acid → (1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester (116404-34-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 5h;

DOI:10.1021/jm00119a024

Reference yield:

((1S,4S)-4-Allyl-1,8-diethyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-acetic acid (106500-01-0,116404-33-2,106464-24-8) → (1R-cis)-1,8-diethyl-2,3,4,9-tetrahydro-4-propyl-1H-carbazole-1-acetic acid 2-(4-bromophenyl)-2-oxoethyl ester (116404-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / hydrogen / Pd/C / methanol / 1.5 h

2: 83 percent / triethylamine / dimethylformamide / 5 h

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00119a024

upstream raw materials:

para-bromophenacyl bromide

((1S,4S)-4-Allyl-1,8-diethyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-acetic acid