1-Acetyl-L-prolyl chloride

Base Information

Chemical Name:1-Acetyl-L-prolyl chloride
CAS No.:72983-26-7
Molecular Formula:C₇H₁₀ClNO₂
Molecular Weight:175.615
Hs Code.:
DSSTox Substance ID:DTXSID90573516
Wikidata:Q82462253
Mol file:72983-26-7.mol

Synonyms:72983-26-7;1-Acetyl-L-prolyl chloride;DTXSID90573516

Suppliers and Price of 1-Acetyl-L-prolyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-Acetyl-L-prolyl chloride

Chemical Property:

PSA：37.38000
LogP:0.70060
XLogP3:0.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:175.0400063
Heavy Atom Count:11
Complexity:193

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CCCC1C(=O)Cl
Isomeric SMILES:CC(=O)N1CCC[C@H]1C(=O)Cl

Technology Process of 1-Acetyl-L-prolyl chloride

There total 3 articles about 1-Acetyl-L-prolyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

: 68-95-1
(S)-acetylproline

: 70935-35-2,72983-26-7
(S)-1-Acetyl-pyrrolidine-2-carbonyl chloride

Guidance literature:: With thionyl chloride; In dichloromethane; at 3 - 30 ℃; for 6h; Temperature;

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 70935-35-2,72983-26-7
(S)-1-Acetyl-pyrrolidine-2-carbonyl chloride

Guidance literature:: acetic anhydride; L-proline; at 20 ℃; Irradiation; Schlenk technique;

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1002/anie.201807027

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 70935-35-2,72983-26-7
(S)-1-Acetyl-pyrrolidine-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / water / 6 h / 8 - 30 °C / pH 7.6

2: thionyl chloride / dichloromethane / 6 h / 3 - 30 °C

With thionyl chloride; sodium carbonate; In dichloromethane; water;