(2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

Base Information

Chemical Name:(2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en
CAS No.:949490-34-0
Molecular Formula:C₃₇H₄₉NO₅Si
Molecular Weight:615.885
Hs Code.:

Synonyms:(2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

Suppliers and Price of (2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

There total 7 articles about (2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 949490-33-9
(2S,3S,4R)-4-benzylamino-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

: 24424-99-5
di-tert-butyl dicarbonate

: 949490-34-0
(2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.tetasy.2007.06.002

Reference yield:

: 949490-32-8
C₂₉H₃₇NO₃Si

: 949490-34-0
(2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / camphor sulfonic acid / 24 h / 20 °C

2: 89 percent / NEt₃ / CH₂Cl₂ / 48 h / 20 °C

With camphor-10-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1016/j.tetasy.2007.06.002

Reference yield:

: 100-46-9
benzylamine

: 949490-34-0
(2S,3S,4R)-4-(N-benzyl-N-tert-butoxycarbonylamino)-1-tert-butyldiphenylsilyloxy-2,3-dioxyisopropylidene-hex-5-en

Guidance literature:: Multi-step reaction with 7 steps

1: MS 4 Angstroem / diethyl ether / 3 h / 20 °C

2: 64 percent / BF₃*Et₂O / diethyl ether / -78 °C

3: 90 percent / tetrahydrofuran; H₂O / 24 h / 20 °C

4: 65 percent / LiOH*H₂O / dioxane; H₂O / 4 h / Heating

5: 85 percent / NEt₃; DMAP / CH₂Cl₂ / 20 h / 20 °C

6: 100 percent / camphor sulfonic acid / 24 h / 20 °C

7: 89 percent / NEt₃ / CH₂Cl₂ / 48 h / 20 °C

With dmap; lithium hydroxide; MS 4 Angstroem; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water;
DOI:10.1016/j.tetasy.2007.06.002