Technology Process of (2R)-(t-butyldiphenylsilyloxy)-1-(tetrahydro-2H-pyran-2-yloxy)hept-6-ene
There total 3 articles about (2R)-(t-butyldiphenylsilyloxy)-1-(tetrahydro-2H-pyran-2-yloxy)hept-6-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2R)-1-(tetrahydro-2H-pyran-2-yloxy)hept-6-en-2-ol;
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
tert-butylchlorodiphenylsilane;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol202541b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 2 h
2.1: iodine; magnesium / tetrahydrofuran / 1.42 h / 20 °C / Inert atmosphere
2.2: -40 - -10 °C / Inert atmosphere
2.3: -40 - 20 °C / Inert atmosphere
3.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
1H-imidazole; iodine; toluene-4-sulfonic acid; magnesium;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
2.1: Grignard reaction / 2.2: Grignard reaction / 2.3: Grignard reaction;
DOI:10.1021/ol202541b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: iodine; magnesium / tetrahydrofuran / 1.42 h / 20 °C / Inert atmosphere
1.2: -40 - -10 °C / Inert atmosphere
1.3: -40 - 20 °C / Inert atmosphere
2.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
1H-imidazole; iodine; magnesium;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: Grignard reaction / 1.2: Grignard reaction / 1.3: Grignard reaction;
DOI:10.1021/ol202541b
