4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide

Base Information

Chemical Name:4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide
CAS No.:1206791-26-5
Molecular Formula:C₃₀H₄₁N₃O₄
Molecular Weight:507.673
Hs Code.:

Synonyms:4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide

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Chemical Property of 4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide

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Technology Process of 4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide

There total 5 articles about 4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1114573-35-1
(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-3-[(S)-1-(4-piperidin-4-yl-phenyl)-ethyl]-[1,3]oxazinan-2-one

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1206791-26-5
4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1206791-26-5
4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 2585.81 Torr

3: trifluoroacetic acid / dichloromethane / 20 °C

4: pyridine / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; potassium carbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1114573-33-9
4-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1206791-26-5
4-((S)-4-{1-[(S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}phenyl)piperidine-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 2585.81 Torr

2: trifluoroacetic acid / dichloromethane / 20 °C

3: pyridine / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;