7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 220835-37-0
• Molecular Formula: C₁₈H₁₀BrCl₂N₃
• Molecular Weight: 419.107

Synonyms:7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property of 7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

There total 2 articles about 7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

7-(4-bromo-phenyl)-5-(4-chloro-phenyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one (220835-23-4) → 7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine (220835-37-0)

Guidance literature:

With trichlorophosphate; for 17h; Heating;

DOI:10.1002/jhet.5570350609

Reference yield:

2-Amino-1-(4-bromo-phenyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile (115998-24-8) → 7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine (220835-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / 10 h / Heating

2: 86 percent / POCl₃ / 17 h / Heating

With trichlorophosphate;

DOI:10.1002/jhet.5570350609

Reference yield: 71.0%

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + 7-(4-bromo-phenyl)-4-chloro-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine (220835-37-0) → 3-(4-bromo-phenyl)-1-(4-chloro-phenyl)-3H-3,4,5a,11-tetraaza-cyclopenta[a]anthracen-6-one

Guidance literature:

for 0.15h; microwave irradiation;

upstream raw materials:

7-(4-bromo-phenyl)-5-(4-chloro-phenyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

2-Amino-1-(4-bromo-phenyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile

Downstream raw materials:

7-(4-bromo-phenyl)-9-(4-chloro-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine

[7-(4-bromo-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

7-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

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